Medications for AD/HD have become one of the most prescribed medications; especially high school kids. In fact the most recent number suggest that about 10% of all high school boys are on an ADD or AD/HD medication. This is an alarming statistic. because it is well know these medications are addictive and have numerous negative side effects. Of course, the doctors always say, “The benefit outweighs the risk.” Easy for them to say, right?
This is where supplements like nootropics can be of great benefit for those not wanting to put their kids on these potentially dangerous drugs. Of course with so many nootripics on the market, it can be daunting to find the right one to sue for this type of problem.
Don’t worry, I got you covered. In this article from Nootripix.com website, they review a very new nootropic that appears to have great promise in treating ADD/ADHD:
“Originally known as NS-105, Fasoracetam is one of the newest nootropics on the market. Besides being the latest racetam to be discovered, it has some unique properties unlike any other racetam on the market. Let’s find out what makes this substance a truly unique nootropic, and why you should (or should not) add it to your stack.
One of the primary effects of Fasoracetam is the modulation of metabotropic glutamate receptors II and III (mGluR).[1] mGlu receptors have been shown to be involved in synaptic plasticity and neuroprotection. In addition, LY354740, am mGlu2/3 agonist, has been shown to be effective in generalized anxiety disorder.[2]
Fasoracetam is also the only racetam that significantly enhances cAMP formation[3] and that has been shown to be effective in ADHD, particularly in individuals with glutamatergic gene variants[4], and a Phase III clinical trial is near completion.
Fasoracetam in animal studies has also shown to have antidepressant effects[5] and to counteract learned helplessness, an avoidance behavior typically associated with depression. Fasoracetam, however, does not act on serotonin or other monoamines, and researchers think the antidepressant effect may stem from its ability to upregulate GABA-B receptors.[6]
Generally speaking, Fasoracetam has shown to be more effective with chronic use, and, in the ADHD study, the peak effects in were felt in week five.[7]
Mechanism of Action
In rat studies, fasoracetam restores the function of key receptors, glutamate mGluR II and III[8]. It also upregulates GABA-B receptors through receptor antagonism[9], a fact which may be related to its ability to reverse phenibut tolerance (which is one of the few supplements reported to relieve anhedonic depression). The GABA-B receptor is very important and has been found to play a role in cognition[10], anxiety and mood.
Alcohol, a very disinhibiting and fog-inducing compound (with pleasurable effects similar to phenibut) is thought to achieve its activity by activating GABA-B and A receptors (as well as dopamine). However, because it downregulates these receptors, prolonged use may cause anxiety and cognitive disruptions. Phenibut binds in a similar fashion to GABA-B.
Because of its relatively narrow range of receptor targets, fasoracetam does not feel like a classic stimulant nor does it alter one’s feeling of wakefulness. It lacks clinical dopamine activity but remarkably still manages to address ADHD symptoms. It significantly increases acetylcholine but remarkably does not cause mood disturbances or depression. It is not clear how fasoracetam has such a specific utility in treating ADHD. More research on other neurotransmitters may be turned up in coming years, but judging on present evidence, it seems that Fasoracetam can reduce ADHD symptoms by modulating glutamatergic receptors.
Although it is a newer supplement without much of a user-base, it does appear to be well-tolerated even in large doses or extended periods. Among college students, it may soon become a mainstay, alongside other trusted nootropics such as Bacopa, Modafinil, and Noopept.”
The rest of the article goes on talk about the role of acetylcholine, glutamate, and GABA as well as the half life of these supplements and proper dosing. Go check out the rest of this info on the Nootropix blog so you can be more informed should you wish to try these on your children: Just click the link below to get there:
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